Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model

Abstract

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane (IM) to create a graft bed that optimizes bone regeneration. The results showed that scraping the inner surface of the induced membrane provided a highly desirable environment that promoted more bone regeneration by exposing the autograft placed in the defect site to fresh blood and competing non-osteogenic cells.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1013538

Entities

People

  • G. E. Pluhar

Organizations

  • University of Minnesota

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Autografts
  • Bone Regeneration
  • Cartilage
  • Casualties
  • Connective Tissue
  • Environment
  • Gene Expression
  • Growth Factors
  • Medical Personnel
  • Membranes
  • Osteogenesis
  • Predictive Modeling
  • Soft Tissues
  • Statistical Analysis
  • Surgery
  • Tissues
  • Wounds And Injuries

Readers

  • Trauma Surgery or Emergency Medicine.