A Structural Biology and Protein Engineering Approach to the Engineering Highly Proficient Catalytic Bioscavengers for In Vivo Detoxification of a Broad Spectrum of Nerve Agents

Abstract

This final report covers the period August 2015 - May 2016. We continued to pursue our integrated computational design (University of Washington, Seattle, USA) and the experimental approach of directed evolution (Weizmann Institute, Rehovot, Israel), the two basic technologies described and implemented throughout this effort. The achievements during this period, including the isolation of adequately proficient VX and RVX degrading enzyme variants, are summarized on pages 2-3 of this report.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 2016
Accession Number
AD1017167

Entities

People

  • Dan S Tawfik
  • David Baker
  • Joel L. Sussman

Organizations

  • Weizmann Institute of Science

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Crystal Structure
  • Detoxification
  • Engineering
  • Genetic Structures
  • Molecular Biology
  • Nerve Agents
  • Organophosphates
  • Organophosphorus Compounds
  • Pharmacology
  • Rodents
  • Therapy
  • Toxicology

Readers

  • Joint Military Operations and Doctrine.
  • Neurotoxicology
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology