Crosstalk between mTORC1 and cAMP Signaling

Abstract

Mutation in TSC1 and TSC2 genes are responsible for tuberous sclerosis complex (TSC). The major function of TSC1/2 is to inhibit mTORC1, thus, uncontrolled mTORC1 activation is the key for TSC. This project studies the molecular mechanisms of negative regulation of mTORC1. We have shown that mTORC1 is potently inhibited by hormones that stimulating cAMP, which acts through protein kinase A (PKA) to inhibit mTORC1. We observed the mTORC1 is inhibited by osmotic stress and possible role of the NLK kinase in mTORC1. We also discovered that different amino acids stimulate mTORC1 by different mechanisms.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1019338

Entities

People

  • Kun-liang Guan

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Growth Factors
  • Health Services
  • Insulin
  • Intellectual Property
  • Materials
  • Metabolism
  • Neutral Amino Acids
  • Oxidative Stress
  • Proteins

Fields of Study

  • Medicine

Readers

  • Aquatic Ecology
  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics