Heterotopic Ossification Following Extremity Blast Amputation: An Animal Model in the Sprague Dawley Rat

Abstract

Prior phase I protocols demonstrated water and the hind limb as the preferred medium and location in the animal model. Phase II demonstrated increased tissue damage from pulsed lavage, and a beneficial effect from amputation above the zone of blast injury. Phase III was designed to investigate effects of nonsteroidal anti-inflammatory (NSAID) medication and external beam radiation on development of HO; prior studies served as the control group in order to limit animal numbers.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2016
Accession Number
AD1023944

Entities

People

  • Vincent Jr D. Pellegrini

Organizations

  • Medical University of South Carolina

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Debridement
  • Health Services
  • Medical Personnel
  • Orthopedics
  • Osteogenesis
  • Residual Limbs
  • Surgery
  • Wounds And Injuries

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Trauma Surgery or Emergency Medicine.