Antimicrobial Silk Ocular Drug Delivery Implant for Chronic Posterior Segment Diseases

Abstract

An intreocular insert based on fibroin was designed and optimized. The insert contains a hollow channel that was preloaded with the anti-VEGF antibody bevacizumab. The device was covalently coated with the antibacterial polymer HMPE1 to protect against biofilm formation and the transmission of harmful bacterial to the interior of the ocular chamber.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2016
Accession Number
AD1028459

Entities

People

  • David L. Kaplan
  • Irmgard Behlau

Organizations

  • Tufts University

Tags

DTIC Thesaurus Topics

  • Amino Acids Peptides And Proteins
  • Anti-Infective Agents
  • Antibodies
  • Biomolecules
  • Biopolymers
  • Blood Proteins
  • Chemical Compounds
  • Immunoglobulins
  • Immunoproteins
  • Macromolecules
  • Polymers

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).
  • Surface Engineering/Surface Coating Technology.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech