Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry

Abstract

The mammalian odorant receptors (ORs) form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niches within their G-protein coupled receptor (GPCR) framework, but very little is known about the molecular recognition strategies they use to bind and discriminate between small molecule odorants.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 02, 2015
Accession Number
AD1028493

Entities

People

  • Hiroaki Matsunami
  • Jianghai Ho
  • Kevin Ryan
  • Masha Y. Niv
  • Merav Fichman
  • Min T. Liu
  • Stuart Firestein
  • Tali Yarnitzky
  • Yadi Li
  • Zita Peterlin

Organizations

  • City College of New York

Tags

DTIC Thesaurus Topics

  • Aldehydes
  • Biochemistry
  • Biological Sciences
  • Biology
  • Cell Physiological Processes
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Fluorescence
  • Molecules
  • Nervous System
  • New York
  • Proteins
  • Recognition
  • Small Molecules
  • Spreadsheet Software
  • United States

Fields of Study

  • Biology
  • Chemistry

Readers

  • Analytical Chemistry
  • Molecular Genetics
  • Vector-Borne Disease and Entomology