A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury
Abstract
A small, lightweight microsystem has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Furthermore, in semi-chronic experiments in rats with traumatic brain injury (TBI) using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microsystem) and open-loop stimulation (OLS) rats. Specifically, OLS does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury. Prior to implementation in clinical trials, translation to non-human primates (NHPs) is critical. In the last phase of this study, we finalized the optimal design and partitioning of an NHP microsystem that is small enough to fit inside a custom-designed, skull-mounted, plastic chamber and can continuously operate for two months from a single 1,600mAh battery placed inside a primate jacket. Follow-on support will allow testing of ADS with this new microsystem in the NHP model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2015
- Accession Number
- AD1032841
Entities
People
- Pedram Mohseni
- Randolph J Nudo
Organizations
- Case Western Reserve University