Threshold Switchable Particles (TSPs) To Control Internal Hemorrhage
Abstract
The final goal of this project was to develop smart particles to stop internal hemorrhage at local sites. Four collaborating laboratories worked together under this contract to define threshold levels of activators of blood clotting such that the candidate clotting activators will circulate in the blood at a concentration below the threshold necessary to trigger clotting, but accumulation of the activators at sites of internal injury/bleeding will cause the local concentration of clotting activators to exceed the clotting threshold and restore hemostasis. During the past year we have applied our improved methods for covalently attaching inorganic polyphosphate (a potent initiator and accelerator of blood clotting) to nanoscale solid supports including silica- and gold-based nanoparticles that have been fabricated using a variety of derivatization and passivation methods. We have conducted extensive testing of candidate procoagulant nanoparticles to quantify their ability to trigger and/or accelerate blood clotting and have made significant progress toward the goal of adjustable procoagulant activities of the particles to render them sub- or supra-threshold with regard to initiation of the clotting cascade.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2016
- Accession Number
- AD1035683
Entities
People
- Christian Kastrup
- Galen D Stucky
- James H Morrissey
- Rustem F. Ismagilov
- Ying Liu
Organizations
- University of Illinois Urbana–Champaign