Combined Effects of Primary and Tertiary Blast on Rat Brain: Characterization of a Model of Blast-Induced Mild Traumatic Brain Injury

Abstract

We hypothesize that the biomechanical perturbations of the brain that yield blast-induced mTBI in injured warfighters can be recreated with reasonable fidelity in rats under carefully controlled experimental conditions, and that several of the characteristic sequelae of blast-induced mTBI observed clinically can be reproduced in a rodent injury model. In many, if not most circumstances yielding blast mTBI, brain injury results from a combination of blast overpressure (BOP) (i.e. primary blast) and head acceleration and/or impact (i.e. tertiary blast). The mTBI resulting from these combined insults may be fundamentally different from that seen from either insult alone.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2016
Accession Number
AD1038958

Entities

People

  • Joseph Long

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Neurodegeneration

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Explosive Engineering.
  • Neurotrauma and Rehabilitation Medicine.