Protective Role of Angiogenin Against Hematopoietic Syndrome of the Acute Radiation Syndrome

Abstract

We have fully documented the function of angiogenin (ANG) in protecting and mitigating damages caused by radiation exposure. We have examined the effect of ANG deficiency on HSPC, LymPro, MyePro, and found that ANG deficiency the number of HSPC, LymPro, and MyePro. We have also found that ANG deficiency resulted in more active cycling of HSPC and LymPro but restricted cycling of MyePro. As the consequence of ANG deficiency on hematopoietic cells, we found that ANG deficiency reduced animal survival upon exposure to radiation.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2017
Accession Number
AD1043615

Entities

People

  • Guo-fu Hu

Organizations

  • Tufts Medical Center

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Cell Physiological Processes
  • Cells
  • Health Services
  • Hematopoietic Cells
  • Medical Personnel
  • Myeloid Cells
  • Proteins
  • Stem Cells

Fields of Study

  • Medicine
  • Physics

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