Low Cost, High-Throughput 3D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low Field MRI
Abstract
According to the original statement of work we have focused our activities on three specific aims. With regards to Aim 1, we have completed the design and prototyping of 129Xe automated hyperpolarizer and began polarizer prototype/final design construction and testing; With regards to Aim 2, we have focused a considerable amount of time on investigating the fundamental parameters of propane hyperpolarization and lifetimes in the gas and liquid phase. In particular, we have studied the pressure dependence of the propane lifetimes and high and low magnetic fields. We also discovered that propane lifetime can be significantly extended in the liquid state. Moreover, we also investigated both approaches: homogeneous and heterogeneous hydrogenation in the context of propane hyperpolarization and demonstrated that up to 9 polarization can be achieved (an order of magnitude improvement vs. preliminary results. These discoveries guided our efforts for the overall propane hyperpolarizer design. Regarding aim 3, we have worked with equipment vendors and finalized the design of the low-field MRI scanner. We also note that we are submitting a duplicating report for two partnering PI awards of the same project: W81XWH-15-1-0271 and W81XWH-15-1-0272.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2016
- Accession Number
- AD1046724
Entities
People
- Boyd M Goodson
Organizations
- Southern Illinois University Carbondale