Diffuse and Focal Brain Injury in a Large Animal Model of PTE: Mechanisms Underlying Epileptogenesis
Abstract
Military traumatic brain injury (TBI) is complex, often involving both diffuse and focal components. The contribution of each of these types of injury to epileptogenic brain activity and ultimately post traumatic epilepsy (PTE) is unclear, as are the mechanisms underlying this transition. Using a large animal model (pig) with adequate white matter pathways and a gyrencephalic brain, we are comparing these injury phenotypes and their potential contribution to PTE. After injury, we chronically implant high density electrodes in the hippocampus, above the cortex near the site of the focal contusion, and ECoG in the contralateral hemisphere. Pigs are monitored via video and electrophysiology up to nine months post injury, and blood biomarkers are being analyzed throughout in order to evaluate them as potential prognostic measures for the development of PTE. A full post-mortem neuropathological examination of axonal and neuronal injury will be performed to have circuitry changes, number and frequency of seizures and inter-ictal events correlated withthe neuropathological outcomes to determine the mechanistic underpinnings of PTE.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2017
- Accession Number
- AD1047469
Entities
People
- John A Wolf