Propagating Molecular Recognition Events through Highly Integrated Sense-Response Chemical Systems
Abstract
General strategies that permit amplification and transduction of molecular recognition events over multiple length scales are of tremendous interest for a range of applications, including advanced sensor design and responsive, smart materials. Liquid crystals (LCs) provide an exciting opportunity in this regard as the supramolecular organization of mesogens within LC phases can be dynamically coupled to nanoscopic and molecular-scale interfacial events such that the response of the LC results in a detectable optical signal on the micrometer length scale. For example, biological recognition events, including enzymatic reactions, occurring at the aqueous interfaces of thermotropic LCs show promise as the basis of biomolecular triggers of LC reorganization that can be conveniently, transduced using optical methods. While several examples of LCs triggered by biomolecular events do exist, general design strategies that can be applied broadly to interfacial assemblies and transformations of biomolecules are yet to be establish. Such principles, if identified, would significantly advance and expand the potential utility of LCs as the basis of triggerable supramolecular materials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2017
- Accession Number
- AD1051298
Entities
People
- Nathan C. Gianneschi
Organizations
- University of California, San Diego