Innervated Blood-Brain-Barrier Tissue for the Study of Neuroinvasion by VEEV

Abstract

With the goal of understanding how Venezuelan equine encephalitis virus (VEEV) infection permeates the blood-brain barrier (BBB), this collaborative project seeks to develop a BBB tissue model that can eliminate many of the shortcomings of current methods to map viral transport and host response in real time by use of an innovative 3D tissue model based on flexible nanoscale field-effect transistor (FET) technology developed in our laboratory. We supported the project's goal of elucidating VEEV pathogenesis by developing, testing and providing to NRL, with appropriate training, nanoFET mesh arrays and measurement systems to develop the BBB model. We also developed sensing strategies based on chemical functionalization of mesh arrays for specific antigen detection in physiological solutions using VEEV analogues.

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Document Details

Document Type
Technical Report
Publication Date
Sep 28, 2018
Accession Number
AD1061593

Entities

People

  • Charles M. Lieber

Organizations

  • President and Fellows of Harvard College

Tags

Communities of Interest

  • Advanced Electronics
  • Human Systems
  • Sensors

DTIC Thesaurus Topics

  • Anhydrides
  • Blood
  • Blood-Brain Barrier
  • Chemistry
  • Connectors
  • Electron Microscopes
  • Electron Microscopy
  • Encephalitis
  • Equine Encephalitis
  • Field Effect Transistors
  • Instructions
  • Medical Personnel
  • Microscopy
  • Proteins
  • Scanning Electron Microscopes
  • Scanning Electron Microscopy
  • Viruses

Readers

  • Integrated Circuit Design and Technology.
  • Nanoscale Plasmonic Nanotechnology
  • Virology (or Medical Virology).