Inflammation Modulatory Protein TSG-6 for Chemical Injuries to the Cornea
Abstract
This project tested the efficacy of the anti-inflammatory protein TSG-6 for the treatment of alkali injury of the cornea in a rat model. We established the time sequence of inflammation, and the cellular and molecular changes which occur after exposure of rat corneas to different concentrations of alkali. These data set the conditions to test the efficacy of topical, intraocular, and intravenous TSG-6, in the promotion of corneal healing and restoration after alkali injury. We found that TSG-6 applied with these methods did not provide a statistically significant benefit to the cornea after alkali injury as evaluated by corneal clarity, although biochemical markers of inflammation suggested limited benefit with intraocular and intravenous application. Further experiments studied the effectiveness of extracellular vesicles, which contain TSG-6, in the treatment of corneal alkali and nitrogen mustard injury, however no significant benefit was observed in these preliminary studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1063917
Entities
People
- Samuel Fulcher