Tailoring Gut Microbiota for Enhanced Resilience and Performance under Sleep-Deprived Conditions
Abstract
Sleep deprivation has been associated with an increase in overall mortality and morbidity in a number of organisms including humans. To address this issue, changes in the gut microbiota and host functions following sleep deprivation were determined in this study, using a humanized rat model derived from transplanting native human microbiota into pseudo germ-free rats. The hypothesis to be tested in this study is that sleep deprivation initially causes degradation in the functional and structural integrity of the gastrointestinal tract, resulting in the leakage of pathogenic microbial cells and factors through the intestine, which in turn induces mucosal and systemic inflammation, dysregulated hypothalamic-pituitary-adrenal axis and ultimately the onset of metabolic disorders.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2019
- Accession Number
- AD1077605
Entities
People
- Amber Braddock
- Armando Soto
- David H Ellis
- Dominique Brown
- Erin Roberts
- Jonathon Soto
- Joshua Bevins
- Judy Triplett
- Kerrine Leguin
- Victor T. Chan
- Victoria Hutzley
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine