CyborgCell: Intracellular Delivery of Molecular and Supramolecular Ionic Circuits for CyborgTissue
Abstract
Cells and cell systems coordinate their birth, growth, proliferation, and death through the exchange of information related to their environment, their function, and their interactions using messenger molecules that encode specific functions. The guided delivery of these molecules can allow programming these cells and systems towards the desired goal. Molecular delivery has been developed for drugs with temporal and spatial control to increase the efficacy of the drug with respect to when the drug freely circulates in the bloodstream. Examples include drug vehicles for delayed release, for targeted delivery using specific antigen molecules present on the desired cell, and vehicles that fall apart when exposed to a given molecule that is overproduced in the area of interest such as reactive oxygen species (ROS) and H+ in areas with inflammation. These advances have greatly increased the efficacy and reduced the side-effects of many treatments. These advances have greatly increased the efficacy and reduced the side-effects of many treatments. Temporal control in biologically relevant timescales (ms) and single cell spatial control (10 micrometer) are important and can be achieved designing vehicles that respond to an external trigger.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 2019
- Accession Number
- AD1086057
Entities
People
- Adah Almutairi
- Ali Khademhosseini
- Christine K. Luscombe
- Marco Rolandi
Organizations
- University of Washington