Prostate Cancer Grade Mapping with Transrectal Electrical Impedance Tomography
Abstract
The primary objective of this research is to combine advanced integrated electronics with transrectal electrical impedance tomography (TREIT) and electrical impedance sensing biopsy (EIS-Bx) devices to improve TRUS-guided prostate biopsy procedures and help to address the challenge of distinguishing aggressive from indolent disease in men newly diagnosed with prostate cancer. The novelty in this program falls into two categories: 1) we aim to couple our single point EIS-Bx measurement device with an array of electrodes adhered to a standard end-fired TRUS probe (Halters team) and 2) we aim to develop a custom application specific integrated circuit (ASIC) that will enable us to measure these electrical properties over a wide frequency range (optimal for discriminating high from low-grade prostate cancer) and at high frame rates (required for real-time prostate biopsy procedures) (Odames team). During the third year of this program we have continued to 1) optimize and validate our initial ASIC device and small form-factor EIT system, 2) optimize finite element method meshing approaches and reconstruction algorithms for imaging the electrical properties of prostate during an TREIT + EIS-Bx procedure, 3)conducted phantom and ex vivo animal tissue studies in preparation for ex vivo prostate studies, and 4) completed submission and received approval for human subjects testing. Over the next year, our plans are to primarily focus on conducting the ex vivo prostate study, while continuing to optimize the hardware and image reconstruction algorithms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1095412
Entities
People
- Kofi Odame
- Ryan Halter