Synthesis and Kinetics of Disassembly for Silyl-Containing Ethoxycarbonyls Using Fluoride Ions
Abstract
In this study, a series of silyl-containing ethoxycarbonates and ethoxycarbamates on electron poor anilines and phenols were synthesized and their kinetics of disassembly determined in real-time upon exposure to fluoride ion sources at room temperature. The results provide a greater understanding of stability and kinetics for silyl-containing protecting groups that eliminate volatile molecules upon removal, which will allow for simplification of orthogonal protection in complex organic molecules.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 22, 2017
- Accession Number
- AD1100497
Entities
People
- Erick B Lezzi
- Eugene Camerino
- Grant C. Daniels
- James H Wynne
Organizations
- United States Naval Research Laboratory