A Targeted Alpha Particle Radiopharmaceutical for Bone Metastatic Breast Cancer

Abstract

The proposed studies will develop and evaluate a new therapeutic strategy for treating breast cancer bone metastasis by disrupting the interactions between breast cancer cells and sensory neurons within bone using alpha particle-emitting radiopharmaceuticals that target the CGRP-CRLR axis. The successful completion of this project will establish a new therapeutic target for cancer-induced bone pain and bone metastatic breast cancer; while providing the foundation required to develop new therapies that will decrease suffering and improve survival of breast cancer patients with bone metastases.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1105452

Entities

People

  • Thaddeus J Wadas
  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Bone Diseases
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Oncology
  • Peripheral Nervous System

Fields of Study

  • Medicine

Readers

  • Oncology (Cancer Research).