Bioinspired Color and Near-Infrared Endoscopy with Affibody Targeted Markers for Colorectal Cancer Surgery
Abstract
Every year, more than 140,000 people are diagnosed with colorectal cancer (CRC) in the US and about 50,000 succumb to the disease. The Veterans Affairs Central Cancer Registry reports that 3,500 VA patients are diagnosed with CRC and 1,200 will succumb to the disease each year. This abysmal outcome in both civilian and military populations is largely caused by the late diagnosis of CRC, when prognosis is poor. To overcome these health issues, we propose to develop an imaging system capable of simultaneously imaging two affibody peptides labeled with near infrared fluorophores targeting epidermal growth factor receptors, HER1 and HER2 (Aim 2). The proposed technology is broadly applicable to many types of solid tumors, but concerted efforts will be directed toward detection of flat lesions of colitis-associated cancer (CAC and dysplasia. The proposed imaging sensor, based on the evolutionarily honed, highly effective visual system of the mantis shrimp, enables a compact, low-noise, ultra-sensitive device realized by combining vertically stacked photodetectors with pixelated spectral filters (Aim 1). We will optimize two affibody-based molecular agents for simultaneous imaging of different tumor biomarkers and evaluate tumor detection sensitivity and specificity in both small and large animals (Aim 3). We hypothesize that a highly sensitive bioinspired color-fluorescence endoscope, in conjunction with a cocktail of small-sized near-infrared molecular probes for targeted imaging, will detect cancerous and pre-cancerous tissue with high specificity and sensitivity in CRC and CAC patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2020
- Accession Number
- AD1117652
Entities
People
- Shuming Nie
- Viktor Gruev
Organizations
- University of Illinois Urbana–Champaign