Sub-Anesthetic Intravenous Ketamine Infusion on Behavior, Biomarkers, and Fear Memory in Male Sprague-Dawley Rats

Abstract

Ketamine is a multimodal dissociative anesthetic and potent analgesic administered to the combat wounded following traumatic injury. Since ketamine induces transient psychosis effects, there are concerns regarding its impact on the development of stress related disorders. There are a limited number of pre-clinical rodent investigations that have examined the effects of post-fear conditioning ketamine on fear memory and PTSD-like behaviors. However, there are no pre-clinical investigations that administered post-fear conditioning ketamine via the intravenous (i. v.) route to rodents to measure outcomes on fear memory processes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 02, 2017
Accession Number
AD1128329

Entities

People

  • Kennett D. Ii Radford

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Advanced Electronics
  • Human Systems

DTIC Thesaurus Topics

  • Analgesia
  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Chemical Synthesis
  • Chemistry
  • Combat Casualty Care
  • Combat Injuries
  • Depression
  • Drug Abuse
  • Health Services
  • Information Processing
  • Liquid Chromatography
  • Medical Personnel
  • Military Medicine
  • Neurosciences
  • Pain
  • Pharmacology
  • Psychiatry
  • Traumatic Stress Disorder

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Trauma Surgery or Emergency Medicine.