Evaluating Effects in the Relationship Between Traumatic Brain Injury and Alzheimer's Disease: Epidemiological Determinants, Their Health-Related Causes, and the Resulting Disparities
Abstract
The primary completed deliverable of this reporting period was the development of partitioning models for Alzheimers disease (AD) and related dementia(ADRD) prevalence and mortality. We found that the prevalence of AD was increasing between 1992 and 2011 and declining thereafter, while incidence based mortality (IBM) increased over the study period with a significant slowdown in its rate of growth from 2011 onwards. For ADRD, prevalence and IBM increased through 2014 prior to taking a downwards turn. The primary determinant responsible for declines in prevalence and IBM was the deceleration in the increase and eventual decrease in incidence rates through changes in relative survival begun to affect the overall trends in prevalence/IBM in a noticeable manner after 2008. Other components showed only minor effects. The prevalence and IBM of ADRD is expected to continue to decrease. The directions of these trends for AD are not clear because AD incidence, the main contributing component, is decreasing and at a decreasing rate suggesting a possible reversal. Furthermore, emerging treatments may contribute through their effects on survival. Improving ascertainment of AD played an important role in trends of AD/ADRD over the 1991-2009/10 period but this effect has exhausted itself by 2017.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2022
- Accession Number
- AD1177035
Entities
People
- Arseniy P Yashkin
- Igor Akushevich
- Larry Tuple
- Murali Doraiswamy
Organizations
- Duke University