The Mechanism of Cutaneous Injury by Mustard Gas. An Experimental Study Using Mustard Prepared with Radioactive Sulfur

Abstract

An investigation was made of the mechanism of vesication through parallel histological and chemical studies of skin exposed to mustard with radioactive sulfur. The rate at which mustard penetrates the skin, the subsequent fate of the penetrated mustard in the skin, and the significance of these chemical data in relation to the production of injury were studied. The pathology of cutaneous injury in man following exposure to mustard was compared with that occurring in animals. The correlation of fixed mustard to the severity of injury, the rate of disappearance in human skin tissue, and the mechanism of the reaction which produced fixed mustard are discussed. Details of experimental procedure are given, and the synthesis of mustard gas containing radioactive sulfur is described.

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Document Details

Document Type
Technical Report
Publication Date
May 09, 1944
Accession Number
AD1184214

Entities

People

  • A. R. Moritz
  • F. C. Jr Henriques
  • H. S. Breyfogle
  • L. A. Patterson

Organizations

  • Harvard University

Tags

Communities of Interest

  • Counter WMD
  • Human Systems
  • Weapons Technologies

DTIC Thesaurus Topics

  • Accuracy
  • Albumins
  • Alkanes
  • Amines
  • Amino Acids
  • Beta Particles
  • Blood
  • Blood Plasma
  • Blood Proteins
  • Body Fluids
  • Cells
  • Cellular Structures
  • Chemical Analysis
  • Chemical Reactions
  • Connective Tissue
  • Materials
  • Measurement
  • Medical Personnel
  • Sites
  • Tissues

Fields of Study

  • Biology

Readers

  • Geochemistry
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology