Simultaneous Multinuclear (Na+/H+) Metabolic MRI For Sodium-, pH-, and Oxygen-Sensitive Images in Human Brain Tumors
Abstract
Over the last reporting period we have (Aim 1) developed an interleaved Na+/H+ MR spectroscopic sequence, interleaved gradient echo(GRE) imaging sequence, and completed an initial prototype of our initially proposed interleaved pH, O2, and sodium-weighted sequence.We have enrolled 6 pre-operative patients (Aim 2) and obtained image-guided biopsies of areas thought to have high acidity, hypoxia, and sodium concentration with the goal of next correlating with tissue biology including NHE1 expression on IHC and RNA sequencing, as well as correlating with bioenergetics once we reach 50% recruitment. Lastly (Aim 3), we have obtained pre- and post-immunotherapy pH,O2, and sodium-weighted MR images in 5 recurrent glioblastoma patients with the goal of next correlating with changes in patient outcome and tissue biology. Initial results suggest a positive correlation between change in imaging measures of rNHE and change in tumor volume after immunotherapy, as well as a correlation between a sodium concentration and diffusion MR measurements, pH imaging measurements,and absolute tumor volume.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1190856
Entities
People
- Benjamin M Ellingson
Organizations
- University of California, Los Angeles