Advanced MR Flow Imaging to Better Identify and Characterize High-Risk Dural Arteriovenous Fistulas
Abstract
To overcome the challenges with MRI-based technique to diagnose dural arteriovenous fistulas DAVFs, which is the most dangerous vascular malformation affecting the brain and causes intracranial hemorrhage and mortality, our proposal is aimed to stratify risk of DAVF based on cortical venous drainage using advanced techniques including 7T MRI with ferumoxytol contrast agent and 3T MRI using gadolinium contrast agent. The proposed hypothesis is 7T MRI will be able to accurately identify DAVFs at high risk for causing hemorrhage compared to the "gold standard" diagnostic cerebral angiogram, and that 3T MRI using gadolinium contrast will provide comparable to 7T MRI primarily by leveraging acquisition of secondary hemodynamic characteristics of DAVFs. The study proposes to validate this hypothesis in 40 adult subjects. In this quarterly report, we present our progress with respect to the approved Statement of Work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1191319
Entities
People
- Matthew Amans
Organizations
- University of California, San Francisco
- Veterans Administration Medical Center