Engineered Development: Human Cardiac Developmental Tissue Model for Multifactorial Screening for the Onset of Congenital Heart Defects
Abstract
In this project, we propose to create a tissue model of congenital heart disease (CHD) by combining the principles of tissue engineering and developmental biology. The proposed tissue model will be treated with different toxic agents known to create CHDs in the body including alcohol, cigarette smoke, and the psychiatric drug lithium. We will look to understand whether these toxins affect heart tissue formation and their role on the genetic makeup of different heart cell types. This proposed research would be the first three-dimensional tissue model that can act as a disease-in-a-dish model of CHD. The proposed model will be useful going forward as a way to potentially predict the formation of CHD, act as a toxin screening model for the formation of CHD, and act as a drug screening model to help treat CHD in the future.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2022
- Accession Number
- AD1211488
Entities
People
- Harald Ott
Organizations
- Massachusetts General Hospital