Injectable Antimicrobial Hydrogel for Extremity Wound Management
Abstract
Effective treatment of war wounds in the forward combat setting and primary care facilities remains a significant challenge facing the military medical community. Battle wounds often necessitate early irrigation, debridement, and antibiotic therapy at the far-forward hospitals. Approximately 20% of battlefield wounds are bone fracture and loss at the extremities. However, antibiotic resistance remains a significant problem at primary military medical facilities, occurring in approximately 15% of surgical patients. The goal of this study is to developed a single-dose, injectable, prolonged nitric oxide (NO*) hydrogel-delivery system to treat deep wound infection and promote tissue regeneration. We hypotheses that (1) device formulations that release as low as an average of 20 M/h NO*(approximately 6 nmol/h/cm2) for at least 18 hours will be bactericidal and biocompatible to mammalian cells in vitro and that (2) a totalNO* dose of 30 moles/cm2 in the 5-mm defect will be bactericidal and promote bone regeneration in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1226985
Entities
People
- Juan M Taboas
Organizations
- University of Pittsburgh