Determination of Subpicogram Quantities of Drugs and Narcotics in Urine of Human Subjects.
Abstract
The urinary excretions of methaqualone and 6-hydroxymethaqualone (free and conjugated) were studied in a normal male subject over a period of 30 days using stable isotope dilution analysis and field ionization mass spectrometry. The terminal half-lives of three compounds were estimated to be about 70 hr. These results were tentatively interpreted in terms of a multicomponent pharmacokinetic model. The ability of isotope dilution analysis using field ionization mass spectrometry to detect minute quantities of drugs in urine was thoroughly evaluated by these experiments. The sensitivity limit was between 0.1 and 1 ng/ml of urine, and was primarily limited by the chemical purity of the isolated drug or metabolite. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1976
- Accession Number
- ADA039107
Entities
People
- Henry D'a. Heck
- James H. Mcreynolds
- Michael Anbar
Organizations
- SRI International