Acquired Immunity to Pathogenic Fungi.
Abstract
Dermatophyte infections are being studied in germfree and conventional rats and guinea pigs and nude mice. The rat is a good model for dermatophyte infections. The primary infection is not as severe as in guinea pigs. An erythema-like reaction (with hyphae in the skin) clears in the germfree rat in 13-14 days and the hair grows back. Conventional rats manifested signs of low grade infection, no hair regrowth for 60-70 days. The germfree rat does not manifest infection with E. floccosum or M. canis. Comparison of infection in germfree and conventional guinea pigs indicates that a skin infection does occur in the germfree guinea pigs but the primary course of infection is twice as long as in the conventional guinea pigs. No colonization of the GI tract of germfree guinea pigs was observed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1976
- Accession Number
- ADA044322
Entities
People
- Edward Balish
Organizations
- University of Wisconsin–Madison