Quantitative Determination of Substances of Biological Activity by Field Ionization and Field Desorption Mass Spectrometry.

Abstract

The objective of this project has been to develop instrumentation and methodologies for quantitative determination of nanomole and possibly picomole amounts of materials of biological interest using field desorption (FD) and isotope dilution techniques. In the first two-year phase of this program, it was intended to develop a number of FD techniques and select the best of these for quantitative assay. To achieve the latter goal a CEC 21-110B double focusing mass spectrometer was modified to accommodate an FI-FD source. It was planned to use the integrating capability of the photoplate attachment for quantitative assay - to overcome the intrinsic fluctuations of FD sources. Most of the effort of the first year has been invested in the modification of the CEC mass spectrometer and in the development of ion sources.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1977
Accession Number
ADA045904

Entities

People

  • G. A. St. John
  • J. H. Mcreynolds
  • M. Anbar

Organizations

  • SRI International

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Amplifiers
  • Biological Sciences
  • Biomedical Research
  • Desorption
  • Geometry
  • High Temperature
  • High Voltage
  • Infectious Diseases
  • Ion Sources
  • Ionization
  • Ions
  • Mass Spectrometers
  • Mass Spectrometry
  • Materials
  • Power Amplifiers
  • Spectrometers
  • Spectrometry

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Plasma Physics.
  • Systems Analysis and Design