Metabolism of Hydrazine.
Abstract
A closed, vacuum tight animal maintenance system has been devised that enables recovery of very small amounts of respiratory 15N over extended periods. Animals with indwelling cannulas for injection and sampling are placed in a closed, circulating atmosphere of 75% SF6/25% O2. CO2 is removed in a soda lime trap, and O2 is added by a peristaltic pump controlled by a pressure sensitive switch. At the time of collection the animal is euthanized and the atmosphere is circulated through a pyrogallol trap to remove most of the oxygen, then transferred by temperature gradient to a high vacuum system where SF6 if frozen out. Preliminary studies of the disposition of intact hydrazine and its derivatives in rats are described. Substantial amounts of a metabolite tentatively identified as diacetyl hydrazine were found in urine. During continuous infusion of hydrazine, some animals maintained a constant blood hydrazine level, others were unregulated and experienced a continuous increase for the duration of infusion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1978
- Accession Number
- ADA062251
Entities
People
- D. L. Springer
- F. N. Dost
Organizations
- Oregon State University