Chemical and Biochemical Studies of PGBX.

Abstract

Over one hundred different samples were tested for their ability to protect isolated rat liver mitochondria from the loss of oxidative phosphorylation; samples were tested at several concentrations and with several different mitochondrial preparations. Results were reported to individuals submitting samples. A comprehensive study of the binding of Ca(++) by PGB sub x and serum albumin by PGB sub x has been completed. The results demonstrate that PGB sub x binds high affinity sites on serum albumin in an area identical to or overlapping Ca(++) binding sites. Physical chemical studies on the binding of Ca(++) by PGB sub x in an aqueous system indicates that a similar interaction occurs in the ionophoretic activity of PGB sub x in the lipid membrane. In very preliminary studies with an isolated perfused heart system, PGB sub x apparently protects the heart during periods of anoxia permitting the heart to resume its function when O2 is administered.

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Document Details

Document Type
Technical Report
Publication Date
Aug 30, 1980
Accession Number
ADA092460

Entities

People

  • Thomas M. Devlin

Organizations

  • Hahnemann University Hospital

Tags

DTIC Thesaurus Topics

  • Absorption
  • Absorption Spectra
  • Albumins
  • Alcohols
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Materials
  • Measurement
  • Mitochondria
  • Mitochondrial Proteins
  • Molecular Weight
  • Molecules
  • Proteins
  • Scattering
  • Silica Gels
  • Spectra

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology