The Synthesis and Evaluation of 15-Keto-PGB1 Analogues.
Abstract
The ethyl analogue, 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone, was prepared as a structurally more suitable model for the investigation of the base promoted conversion of 15-keto-PGB1 to an oligomeric mixture termed PGBx. Base treatment of the ethyl analogue results in the conversion to an oligomeric mixture capable of protecting against the loss of oxidative phosphorylation in isolated mitochondria without inhibition at higher concentrations as observed for PGBx. The chemistry of the oligomerization was investigated and has major implications for an understanding of the complexity of the oligomeric mixture PGBx. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1981
- Accession Number
- ADA098304
Entities
People
- George L. Nelson
Organizations
- University of Saint Joseph