An in vitro Method for the Screening of Trichothecene Mycotoxin Cytotoxicity and the Study of Mycotoxin Countermeasures
Abstract
A thymocytic cell bio-assay was developed for assessing the toxicity of the trichothecene mycotoxin T-2. The in vitro toxicity of mycotoxin T-2 towards mouse mono-nuclear leukocytes prepared from spleen, thymus, peritoneal lavage and bone marrow cells was studied. Bone marrow cells were found to more resistant to T-2 toxicity than thymus, spleen and peritoneal cell preparations. This method is rapid and provides consistant and reproducible results for the study of T-2 mycotoxicosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1985
- Accession Number
- ADA153663
Entities
People
- A. R. Bhatti
- D. Penman
- N. P. Erhardt
- P. A. Lockwood
- V. L. Dininno