Inhalation Toxicology. 4. Times to Incapacitation and Death for Rats Exposed Continuously to Atmospheric Hydrogen Chloride Gas

Abstract

Laboratory rats were exposed continuously to measured atmospheric concentrations of hydrogen chloride (HC1) gas until they expired. The exposure time required to produce lethality was measured, as was the time at which physical incapacitation occurred. Incapacitation was defined operationally as loss of the ability to walk in a motor-driven wheel. These two endpoints, time- to-incapacitation and time-to-death, were equated to atmospheric HC1 concentration by statistically derived regression equations. The possible relationship between the effective toxic doses of HC1 gas for rats and those reported for humans is discussed. Originator supplied keywords include: Combustion toxicology; Smoke, Irritant gas; Time-to-incapacitation; Time-to- death; Aircraft cabin fire.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1985
Accession Number
ADA157400

Entities

People

  • Boyd R. Endecott
  • Charles R. Crane
  • Donald C. Sanders
  • John K. Abbott

Organizations

  • Federal Aviation Administration

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aircrafts
  • Animals
  • Chlorides
  • Combustion
  • Dielectric Gases
  • Equations
  • Fires
  • Flow Rate
  • Gases
  • Incapacitation
  • Laboratory Animals
  • Lethal Dosage
  • Lethality
  • Material Degradation Processes
  • Materials
  • Medical Personnel
  • Rodents

Fields of Study

  • Environmental science

Readers

  • Exercise and Sports Science.
  • Plasma Physics.
  • Toxicology/Environmental Toxicology