Modelling the Somatic Electrical Response of Hippocampal Pyramidal Neurons

Abstract

A modelling study of hippocampal pyramidal neurons is described. Thi s study is based on simulations using HIPPO, a program which simulates the somatic electrical activity of these cells. HIPPO is based on: a) descriptions of eleven non-linear conductances that have been either reported for this class of cell in the literature or postulated in the present study, and b) an approximation of the electronic structure of the cell that is derived in this thesis, based on data for the linear properties of these cells. HIPPO is used: a) to integrate empirical data from a variety of sources on the electrical characteristics of this type of cell, b) to investigate the functional significance of the various elements that underly the electrical behavior, and c) to provide a tool for the electrophysiologist to supplement direct observation of these cells and provide a method of testing speculations regarding parameters that are not accessible.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA216753

Entities

People

  • Lyle Borg-graham

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Advanced Electronics
  • Cyber
  • Energy and Power Technologies
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Artificial Intelligence
  • Brain
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Cognition
  • Cognitive Science
  • Computational Neuroscience
  • Differential Equations
  • Fish
  • Information Processing
  • Lisp Programming Language
  • Maglev
  • Membranes
  • Neurons
  • Neurosciences
  • Synapses

Readers

  • Computational Modeling and Simulation
  • Neuroscience
  • Systems Analysis and Design

Technology Areas

  • Microelectronics