Study of Erythrocyte Lipid Peroxidation and Deformability inIndividuals with Sickle Cell Trait.

Abstract

Tread Mill exercise did not have any significant effect on the lipid peroxidation potential and deformability of RBC in normal (AA) subjects. However, it caused an increase in the lipid peroxidation potential and a loss of deformability of RBC in sickle cell trait (AS) subjects. Increased TBC lipid peroxidation in AS during exercise was accompanied with an accumulation of excessive amounts of superoxide radicals (due to increase in superoxide dismutase activity) and less decomposition of these free radicals. Furthermore, the modulation of peroxide scavengers of RBC in AS during exercise was associated with an increase in the intracellular calcium concentration and an increase in the RBC membrane density. Thus the loss of deformability in AS during exercise may be related to the change in RBC membrane density. Keywords: Sickle cell trait; Physical stress; Lipid Peroxidation; Deformability; RA III.

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Document Details

Document Type
Technical Report
Publication Date
Aug 21, 1989
Accession Number
ADA222063

Entities

People

  • Salil K. Das

Organizations

  • Meharry Medical College

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Blood
  • Blood Cells
  • Cell Membrane
  • Cells
  • Chemistry
  • Death
  • Erythrocytes
  • Fatty Acids
  • Free Radicals
  • Hematologic Diseases
  • Medical Personnel
  • Membrane Proteins
  • Peroxides
  • Sickle Cells
  • Two Dimensional
  • United States

Fields of Study

  • Biology

Readers

  • Exercise and Sports Science.
  • Immunology
  • Immunology and Pathology