The Acute Inhalation Toxicity of Pyrolysis Products of Halon 1301: Exercise Potentiation of Expression of Lung Injury Induced by Compounds 1 and 2
Abstract
This final report summarizes investigations that have focused on the lower respiratory tract toxicities of inhaled perfluoroisobutylene (PFIB/ compound 1) and bis(trifluoromethyl)disulfide (TFD/Compound 2), and it describes how the injurious effects of these compounds may be enhanced by post-exposure exercise and/or result in a reduction in work performance capacity. The major objectives of the project were 1)to determine if the expression of lung injury induced by PFIB and TFD can be increased in severity by post-exposure exercise using lung gravimetric and histopathologic criteria as endpoints, and to characterize the post-exposure period of time during which the expression of PFIB- and TFD-induced lung injury can be potentiated by exercise, i.e., the window of susceptibility.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 30, 1990
- Accession Number
- ADA231615
Entities
People
- Bruce E. Lehnert
- Douglas M. Stavert
Organizations
- Los Alamos National Laboratory