An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity
Abstract
Brain missile wounding (BMW) is accompanied with a concomitant increase in intracranial pressure (ICP). Both, BMW with its accompanying increase in ICP or artificially increased ICP, without wounding, caused significant epinephrine (EPI) depletions (47%-68%) in the nucleus tractus solitarius (NTS), are A1C1, locus coeruleus, raphe nuclei and posterior hypothalamus. EPI was also significantly decreased in the anterior hypothalamus but only in wounded cats. BMW, but not artificially increased ICP, without wounding, also caused significant decreases of norepinephrine (NE), dopamine and homovanillic acid the NTS and area A1C1. We conclude that most of the brain stem and hypothalamic biogenic amine changes were probably caused by the cardiovascular effects associated with the stress of increased ICP alone. The results suggest selective monoamine decreases associated with increased ICP: the EPI system overall and the 5-HT system in the raphe nuclei.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 05, 1990
- Accession Number
- ADA232378
Entities
People
- Michael E. Carey
Organizations
- LSU Health Sciences Center New Orleans