Bridged Bicyclic Systems as Acetylcholinesterase Reactivators and Pretreatment Drugs
Abstract
During the past year, 3-oximinotropan-2-one methiodide has been synthesized as well as the racemic compound 3-oximinotropan-2-one. The regioisomeric 2-oximino-tropan-3-one has been prepared and the corresponding hydrochloride has also been synthesized. Binding constants to AChE, pKa's and reactivation activities for these compound have been determined. Several oximes and a-ketones in the phencyclidine series have also been synthesized and submitted for testing. Among azabicyclooctane derivatives, 2,4-bisoximino tropan-3-one methiodide, 2,4-dimethoxy-3-oximinotropane methiodide and 2- carbomethoxy-3-oximinotropane has been synthesized and submitted for testing. 1- Methyl-3-oximino-5,5-diphenyl azacycloheptan-4-one methiodide has also been synthesized and submitted. A novel type of atropine-like molecule has been made, namely, 3-acetophenyl tropine oxime hydrochloride.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 15, 1989
- Accession Number
- ADA233488
Entities
People
- Robert M. Moriarty
Organizations
- University of Illinois at Chicago