Effects of Hemorrhagic Shock and Retransfusion on Myocardial Beta- Adrenergic Receptors and Adenylate Cyclase Activity
Abstract
Mechanisms for the myocardial dysfunction observed following hemorrhagic shock remain unclear. A well characterized rabbit model was utilized to determine the effects of shock and retransfusion on myocardial beta- adrenergic receptors and adenylate cyclase activity. Hemorrhagic shock was produced by rapid blood withdrawal to reduce mean arterial pressure to 35 mmHg in anesthetized rabbits instrumented for comprehensive hemodynamic monitoring. The shock state was maintained for 60 minutes and then the animals were transfused with the autologous warmed shed blood. Ventricular myocardium was analyzed for dihydroalprenolol binding and adenylate cyclase activity. There was no effect of shock or retransfusion on basal or stimulated adenylate cyclase activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1991
- Accession Number
- ADA236091
Entities
People
- Michael Artman
Organizations
- University of South Alabama