Precomplexation and Activation of Carboxylate and Phosphate Esters
Abstract
We are looking for reaction types that simultaneously: provide for the reaction of acyl and phosphoryl groups under non-forcing conditions; suggest ways for elaboration into catalytic cycles with turnover behavior; and, survive translation onto binding moieties. To date, we have focused on artificial metalloenzymes derived from cobalt(III) and copper(II) coordination complexes with cyclodextrins, preassociating alpha-nucleophiles, and binuclear metal ion complexes. Cyclodextrins have been prepared bearing imidazole as a group with reactivity at pH 7; pendant coordination complexes have likewise been employed. However, as potential pendant groups, alpha-nucleaophiles such as hydrazine or hydroxylamine offer unique properties.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 02, 1992
- Accession Number
- ADA247778
Entities
People
- Anthony W. Czarnik
Organizations
- Ohio State University