Development of Bioelastic Materials for the Prevention of Adhesions: Polypenta- and Polytetrapeptides
Abstract
The purpose of the contract was the development of bioelastic materials for the application of preventing post-surgical and post-trauma adhesions by preparing compliant sheets which can be placed between repair sites and which act as barriers to the formation of adhesions between the repairing sites. Specifically to be prepared were quantities of a series of polypentapeptides and polytetrapeptides which were gamma-irradiation cross- linked to form elastomeric sheets and which were supplied to the Naval Medical Research and Development Command, Combat Casualty Care Unit for the animal model efficacy studies carried out at the Naval Medical Research Institute. In addition, in the process of carrying out the specific objectives, considerations of further applications was stimulated and these stimuli, coming from interactions with Navy personnel and others, have resulted in the development of intellectual property with the support of this contract.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 14, 1993
- Accession Number
- ADA264851