Carboxyalkylated Crosslinked Hemoglobin as a Potential Blood Substitute.

Abstract

Our research supported by this contract has been directed along 3 main lines: (1) analysis of crosslinked hemoglobin samples (64,000 MW) from the U.S. Army Medical Research Detachment headed by Col. John Hess. This has been achieved by various protein separation methods under both native and denaturing conditions in order to monitor the product of the pilot plant. (2) studies on the preparation of higher molecular weight crosslinked hemoglobins (128,000 MW). Various bifunctional agents are being evaluated and (3) studies on recombinant hemoglobins to understand the molecular basis for the low oxygen affinity of certain hemoglobins as a basis for future blood substitute research.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1995
Accession Number
ADA296762

Entities

People

  • James M. Manning

Organizations

  • The Rockefeller University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Substitutes
  • Contracts
  • Hemoglobin
  • Molecular Weight
  • Pilot Plants
  • Proteins

Fields of Study

  • Chemistry

Readers

  • Military Leadership and Professional Education.
  • Molecular and Cellular Biochemistry