Effect of Hormone Replacement Therapies and Dietary Phytoestrogens on the Mammary Gland of Macaques

Abstract

The purpose of this study has been to use histomorphometric and immunohistochemical techniques to study the incidence and characteristics of mammary gland hyperplasia, dysplasia and other possible indicators of breast cancer risk, in cynomolgus macaques given long-term hormonal treatments. Treatments evaluated to date include conjugated estrogens (CEE), medroxyprogesterone acetate (MPA), the combination of CEE and MPA, tamoxifen, estradiol (E2), 17alpha-dihydroequilenin (DHEN), soybean phytoestrogens (SBE), and SBE + E2. Pathologic evaluation, histomorphometric evaluations, and staining for estrogen receptor, progesterone receptor, and the proliferation marker Ki-67 MIB were done.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1997
Accession Number
ADA332648

Entities

People

  • J M Cline

Organizations

  • Wake Forest School of Medicine

Tags

DTIC Thesaurus Topics

  • Alkynes
  • Breast Cancer
  • Cells
  • Chemistry
  • Drug Therapy
  • Estrogens
  • Growth Factors
  • Health Services
  • Liquid Chromatography
  • Medical Personnel
  • Neoplasms
  • Osteoporosis
  • Sex Hormones
  • Therapy
  • Uterine Cancers

Readers

  • Information Retrieval
  • Molecular Biology and Genetics