The BRCA1 Tumor-Suppressor Gene in a Mouse Model of Breast Cancer.
Abstract
BRCA1 is a tumor-suppressor locus on chromosome 17q21. Familial inheritance of a defective copy places a lifetime risk of breast cancer at 80%. Most of these tumors arise before the age of 50. In addition, there is an elevated risk of ovarian and testicular tumors. The mechanism of transformation is not known. In an effort to better understand the actions of this gene, I have cloned the mouse Brca1 gene. The present proposal aims to characterize the effect of over-expression and deletion of Brca1 in mice, and by understanding the nature of the interactions between Brca1 and other oncogenes. The completion of these aims will provide: (1) a mouse model of Brca1 deficiency, (2) an enhanced understanding of Brca1 function in the regulation of mammary epithelial cell growth and differentiation, and (3) reveal important interactions between Brca1 and other potent transforming agents in the breast, in particular with c-myc, and loss of p53.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA366657
Entities
People
- Timothy F. Lane
Organizations
- University of California, Los Angeles