Contract Enhanced 3D Color Amplitude Imaging of Breasts
Abstract
This project is an add-on study to an already funded NIH project aimed at increasing the sensitivity and specificity of breast ultrasound by combining injection of an ultrasound contrast agent with 3D reconstruction of color amplitude images. The fundamental hypothesis is that the neovasculature of malignant lesions can be visualized with this novel combination, thus, improving the diagnosis of breast cancer. Image analysis software for the histomorphometry system has been developed to allow vessel distribution (i.e., histogram) and vessel density maps to be produced from 3D image data. Moreover, 3D parameter extraction algorithms for the LIS 6000A system has been designed and is currently being tested. To date 20 patients with 6 cancers and 14 benign lesions have been enrolled in the study. These numbers are less than anticipated, but efforts have been put in place to increase recruitment. There has been one adverse event. This was properly reported and judged to be a rated side effect of the ultrasound contrast agent which does not require any protocol changes. No data analysis has yet been carried out due to the limited data set available. However, this is expected to commence within the next 3 months.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA368390
Entities
People
- Flemming Forsberg
Organizations
- Thomas Jefferson University