Quantitating the Percutaneous Absorption of Mechanistically Defined Chemical Mixtures

Abstract

The focus of this research was to assess the percutaneous absorption and cutaneous toxicity of jet fuels (Jet A, JP-8, JP-8 +100). The absorption of jet fuel hydrocarbons (naphthalene, dodecane, hexadecane) was studied as a function of jet fuel type and the presence of individual or all possible combinations of performance additives (DIEGME, 8Q2l, Stadis 450). Percutaneous absorption was investigated using in vitro flow-through diffusion cells containing inert silastic or dermatomed pig (Sus scrofa) skin and in isolated perfused porcine skin flaps (IPPSFs). Toxicity was assessed in IPPSFs as well as in human and porcine keratinocyte cell cultures as well as in vivo pigs. All fuels produced evidence of skin toxicity and resulted in production and release of the cytokines IL-8 and TNFalpha. Naphthalene absorption was greater than the aliphatic markers, however skin deposition showed the reverse( pattern; both of which were affected by the addition of performance additives.

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Document Details

Document Type
Technical Report
Publication Date
Feb 02, 2001
Accession Number
ADA386659

Entities

People

  • Charles O Smith
  • Jim E. Riviere
  • Ronald E Baynes

Organizations

  • North Carolina State University

Tags

DTIC Thesaurus Topics

  • Air Force
  • Alkanes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epidermis
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Organic Chemistry
  • Skin Diseases

Readers

  • Petroleum Engineering
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.