A Solid Support Synthesis and Novel Conjugation Methods of Breast Tumor Associated Antigen: Toward the Development of Cancer Vaccines

Abstract

N-linked glycopeptides and glycoproteins are important biomolecules. They been revealed to involve a various biological affairs. For the first time, we have achieved the total synthesis of a high mannose N-linked glycopeptide carrying full H-type II human blood group. In this study, we have developed: (a) an efficient method for constructing core high mannose structure which is essential for all N-linked glycoproteins; (b) a chemically selective and stereoselective method for N-glycosylation of peptide, which will be widely used for making N-glycopeptide for biological study; (c) an efficient synthetic method to prepare the suitably protected lactosamine spacer; (d) an efficient method to construct H-type trisaccharide unit.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA392300

Entities

People

  • Samuel J. Danishefsky
  • Zhi-guang Wang

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anhydrides
  • Blood Groups
  • Breast Cancer
  • Carbohydrates
  • Chemical Synthesis
  • Chemistry
  • Glycoconjugates
  • Glycoproteins
  • Glycosides
  • Neoplasms
  • Organic Chemistry
  • Vaccines

Fields of Study

  • Chemistry

Readers

  • Immunology
  • Organic Chemistry
  • Systems Analysis and Design

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech